Holliday intermediate
Holliday intermediate An intermediate structure in genetic recombination, proposed by Robin Holliday in 1964, in which two double-stranded homologous DNA molecules are joined by means of a reciprocal crossover involving one DNA strand of each molecule. It is formed when a single strand of DNA from each chromosome is broken and joined to the other strand at the point of crossover. The region in which strands from different DNA molecules are paired (a heteroduplex DNA sequence) is extended and two strands of the Holliday intermediate are cleaved. The breaks in the DNA sequences are then repaired to form the recombinant products (see illustration).
More From encyclopedia.com
Crossing Over , Crossing over, or recombination, is the exchange of chromosome segments between nonsister chromatids in meiosis. Crossing over creates new combinatio… Wobble Hypothesis , wobble hypothesis A theory proposed to explain the partial degeneracy of the genetic code in that some t-RNA molecules can recognize more than one co… Mapping , Mapping
Genetic mapping is the process of measuring the distance between two or more loci on a chromosome. In order to determine this distance, a num… Rib , rib / rib/ • n. 1. each of a series of slender curved bones articulated in pairs to the spine (twelve pairs in humans), protecting the thoracic cavit… Dna Hybridization , Evolution deals with heritable changes in populations over time. Because DNA is the molecule of heredity, evolutionary changes will be reflected in c… Genetic Map , genetic map The linear arrangement of mutable sites on a chromosome, deduced from genetic recombination experiments. The percentage of recombinants i…
You Might Also Like
NEARBY TERMS
Holliday intermediate