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- Sluys
- Small Magellanic Cloud
- Smalley, Richard Errett
- smaltite
- smartphone
- smartweed
- smelling salts
- Smerdis
- Smillie, Robert
- Smith, George Elwood
- Smith, Gipsy
- Smith, Goldwin
- Smith, Hamilton Othanel
- Smith, Hoke
- Smith, Kirby
- Smith, Michael
- Smith, Red
- Smith, Sir Harry George Wakelyn
- Smith, Thomas, Captain
