Smithies, Oliver
Oliver Smithies, 1925–, American geneticist, b. Halifax, England, Ph.D., Oxford, 1951. Smithies was on the faculty at the Univ. of Toronto (1953–60) and Univ. of Wisconsin–Madison (1960–88) before becoming a professor at the Univ. of North Carolina at Chapel Hill. With Sir Martin Evans and Mario Capecchi, he was awarded the 2007 Nobel Prize in physiology or medicine, which recognized their contributions to the development of gene targeting, a technique that enables individual genes to be "knocked out" of mice DNA and replaced with others. Smithies went on to use gene targeting to investigate inherited diseases such as cystic fibrosis.
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Regulator Gene , regulatory gene In the operon theory of gene regulation, a gene that is involved in switching on or off the transcription of structural genes. When t… Pseudogenes , Pseudogenes are defective copies of functional genes. These may be partial or complete duplicates derived from polypeptide-encoding genes or RNA gene… Selfish Dna , Evolutionary biologists increasingly accept that genes are selfish. But what does this mean? Clearly genes do not have personal motivations, and even… Operon , Operon
An operon is a genetic regulatory system found in prokaryotes and the bacterial viruses (bacteriophages ) that attack bacteria. It is a cluste… gene family , gene family A group of similar or identical genes, usually along the same chromosome, that originate by gene duplication of a single original gene. S… Nomenclature , Like any other field in science, genetics has its own language. However, genetics is also a multidisciplinary field that encompasses expertise, and h…
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Smithies, Oliver