statin

views updated May 29 2018

statin (stat-in) n. a drug that inhibits the action of an enzyme involved in the liver's production of cholesterol. Statins can lower the levels of low-density lipoproteins (LDLs) by 25–45%; they are used mainly to treat hypercholesterolaemia but also to reduce the risk of coronary heart disease in susceptible patients. See atorvastatin, fluvastatin, pravastatin, simvastatin.

statins

views updated May 29 2018

statins A family of related compounds (lovastatin, pravastatin, simvastatin) used to treat hypercholesterolaemia. They act by inhibiting hydroxymethylglutaryl CoA reductase (HMG CoA reductase), the first and rate‐limiting enzyme of cholesterol synthesis.

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